Trained by John Gosden, the four-year-old filly was a heavy favourite to become the eighth two-time victor of the Arc.
Enable is a relentless galloper and although Dettori elected to sit just off the pace, Prince Khalid Abdulla's filly was always travelling strongly on the heels of the leaders and the packed grandstands roared as she hit the front.
A record sixth Arc for jockey Frankie Dettori, Enable had a short neck in hand over the fast finishing Sea Of Class, trained by Skipton-born William Haggas, who had a nightmare outer draw under jockey James Doyle.
She rattled home once in the clear to set up an epic finish, but Enable had just enough in the tank to claim victory.
Cloth of Stars finished a creditable third.
"It's not been the preparation we wanted, it has been very hard, and we had a hiccup between Kempton and here with a slight temperature thing, so it has not been easy", trainer Gosden told ITV Racing.
Gosden revealed after the victory that Enable also experienced an elevated temperature between her prep race and Sunday's feature, meaning we still may not have seen her best this year. I've had a hard year with her and started with a bit more hair than I have now.
"I don't want to be ungrateful or unsporting - John's filly is brilliant - but let's hope he retires her now and that we can come back next year!" "Enable wasn't at her best today, she's got the job done and it's very much down to her mind and ability".
"She's a wonderful filly and it's an enormous sense of relief".
"It is a crack, she won two Arc", said Lanfranco Dettori arms raised return to the round of presentation.
Gosden also said the owner will make the final decision as to whether Enable will be aimed at November's Breeders' Cup. "He wanted to come here and if she's in good form there's no reason you wouldn't try to come again". Everybody wanted her to win and I had to get it right.
"I don't think the ground is a problem, it was quick when he (Waldegeist) won the Grand Prix de Saint-Cloud - he acts on any sort of ground", said Fabre this week. "She came from the back, and the last 100 metres were long for me - because having taken control of the race she was certainly tiring". I'm thrilled with him and I'm thrilled with the filly.
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